Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

Retinal angiogenesis is tightly regulated to meet oxygenation and nutritional requirements. In diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, uncontrolled angiogenesis can lead to blindness. Our goal is to better understand the molecular process...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Reynolds, Alison L., Alvarez, Yolanda, Sasore, Temitope, Waghorne, Nora, Butler, Clare T., Kilty, Claire, Smith, Andrew J., McVicar, Carmel, Wong, Vickie H. Y., Galvin, Orla, Merrigan, Stephanie, Osman, Janina, Grebnev, Gleb, Sjölander, Anita, Stitt, Alan W., Kennedy, Breandán N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817159/
https://ncbi.nlm.nih.gov/pubmed/26846851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.710665
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