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The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus

Objectives. Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Methods. Forty-eight rats were equally randomized into six groups...

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Detalhes bibliográficos
Publicado no:Ups J Med Sci
Main Authors: Wang, Nan, Yu, Hai-Ying, Shen, Xiao-Feng, Gao, Zhi-Qin, Yang, Chun, Yang, Jian-Jun, Zhang, Guang-Fen
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816884/
https://ncbi.nlm.nih.gov/pubmed/26220286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2015.1060281
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