The rapid antidepressant effect of ketamine in rats is associated with down-regulation of pro-inflammatory cytokines in the hippocampus

Objectives. Active inflammatory responses play an important role in the pathogenesis of depression. We hypothesized that the rapid antidepressant effect of ketamine is associated with the down-regulation of pro-inflammatory mediators. Methods. Forty-eight rats were equally randomized into six groups...

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Bibliographic Details
Published in:Ups J Med Sci
Main Authors: Wang, Nan, Yu, Hai-Ying, Shen, Xiao-Feng, Gao, Zhi-Qin, Yang, Chun, Yang, Jian-Jun, Zhang, Guang-Fen
Format: Artigo
Language:Inglês
Published: Informa Healthcare 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816884/
https://ncbi.nlm.nih.gov/pubmed/26220286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03009734.2015.1060281
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