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Does the mutant CAG expansion in huntingtin mRNA interfere with exonucleolytic cleavage of its first exon?
BACKGROUND: Silencing mutant huntingtin mRNA by RNA interference (RNAi) is a therapeutic strategy for Huntington’s disease. RNAi induces specific endonucleolytic cleavage of the target HTT mRNA, followed by exonucleolytic processing of the cleaved mRNA fragments. OBJECTIVES: We investigated the clea...
Uloženo v:
| Vydáno v: | J Huntingtons Dis |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4816656/ https://ncbi.nlm.nih.gov/pubmed/27003665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-150183 |
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