Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana

An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfuncti...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Fernández-Figueroa, Edith A., Imaz-Rosshandler, Iván, Castillo-Fernández, Juan E., Miranda-Ortíz, Haydee, Fernández-López, Juan C., Becker, Ingeborg, Rangel-Escareño, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816531/
https://ncbi.nlm.nih.gov/pubmed/27031998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004570
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