Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1

The SCF ubiquitin ligase associates with substrates through its F-box protein adaptor. Substrates are typically recognized through a defined phosphodegron. Here, we characterize the interaction of the F-box protein Saf1 with Prb1, one of its vacuolar protease substrates. We show that Saf1 binds the...

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發表在:Biochemistry
Main Authors: Mark, Kevin G., Meza-Gutierrez, Fernando, Johnson, Jeffrey R., Newton, Billy W., Krogan, Nevan J., Toczyski, David P.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816488/
https://ncbi.nlm.nih.gov/pubmed/26161950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00504
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