2-Methoxyestradiol blocks the RhoA/ROCK1 pathway in human aortic smooth muscle cells

2-Methoxyestradiol (2-ME), a metabolite of estradiol with little affinity for estrogen receptors, inhibits proliferation of vascular smooth muscle cells; however, the molecular mechanisms underlying this effect are incompletely understood. Our previous work shows that 2-ME inhibits initiation (block...

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Foilsithe in:Am J Physiol Endocrinol Metab
Main Authors: Rigassi, Lisa, Barchiesi Bozzolo, Federica, Lucchinetti, Eliana, Zaugg, Michael, Fingerle, Jürgen, Rosselli, Marinella, Imthurn, Bruno, Jackson, Edwin K., Dubey, Raghvendra K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2015
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816197/
https://ncbi.nlm.nih.gov/pubmed/26487003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00267.2015
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