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AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation

Nuclear degradation is a key stage in keratinocyte terminal differentiation and the formation of the cornified envelope that comprises the majority of epidermal barrier function. Parakeratosis, the retention of nuclear material in the cornified layer of the epidermis, is a common histological observ...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Naeem, A S, Zhu, Y, Di, W L, Marmiroli, S, O'Shaughnessy, R F L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816115/
https://ncbi.nlm.nih.gov/pubmed/26045045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.62
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