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Single fluorescence probes along the reactive center loop reveal site‐specific changes during the latency transition of PAI‐1
The serine protease inhibitor (serpin), plasminogen activator inhibitor‐1 (PAI‐1), is an important biomarker for cardiovascular disease and many cancers. It is therefore a desirable target for pharmaceutical intervention. However, to date, no PAI‐1 inhibitor has successfully reached clinical trial,...
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| Publicado no: | Protein Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815349/ https://ncbi.nlm.nih.gov/pubmed/26540464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2839 |
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