Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis

Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear. To explore the...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Zhang, Cong-En, Niu, Ming, Li, Rui-Yu, Feng, Wu-Wen, Ma, Xiao, Dong, Qin, Ma, Zhi-Jie, Li, Guang-Quan, Meng, Ya-Kun, Wang, Ya, Yin, Ping, He, Lan-Zhi, Li, Yu-Meng, Tan, Peng, Zhao, Yan-Ling, Wang, Jia-Bo, Dong, Xiao-Ping, Xiao, Xiao-He
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814850/
https://ncbi.nlm.nih.gov/pubmed/27065293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00085
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