Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation

Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodon...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Liu, Jia, Saito, Kan, Maruya, Yuriko, Nakamura, Takashi, Yamada, Aya, Fukumoto, Emiko, Ishikawa, Momoko, Iwamoto, Tsutomu, Miyazaki, Kanako, Yoshizaki, Keigo, Ge, Lihong, Fukumoto, Satoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814822/
https://ncbi.nlm.nih.gov/pubmed/27030100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23670
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