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High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles

AIM: To develop biocompatible, tumor-specific multifunctional iron-oxide nanoconstructs targeting neuroblastoma, an aggressive pediatric malignancy. MATERIALS & METHODS: Clinical-grade humanized monoclonal antibody (hu14.18K322A), designed to target GD2 antigen on neuroblastoma with reduced nons...

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Detalhes bibliográficos
Publicado no:Nanomedicine (Lond)
Main Authors: Baiu, Dana C, Artz, Nathan S, McElreath, Meghan R, Menapace, Bryan D, Hernando, Diego, Reeder, Scott B, Grüttner, Cordula, Otto, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814363/
https://ncbi.nlm.nih.gov/pubmed/26420448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.138
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