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UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development

Landmark epigenetic events underlie early embryonic development, yet how epigenetic modifiers are regulated to achieve rapid epigenome re-patterning is not known. Uhrf1 and DNA methyltransferase 1 (Dnmt1) are known to largely mediate maintenance DNA methylation and Uhrf1 is also required for both Dn...

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Publicat a:Dev Biol
Autors principals: Kent, Brandon, Magnani, Elena, Walsh, Martin J., Sadler, Kirsten C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814311/
https://ncbi.nlm.nih.gov/pubmed/26851214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2016.01.036
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