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Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement–Fluorescence Correlation Spectroscopy

This work describes the use of fluorescence correlation spectroscopy (FCS) and a novel amyloid-binding fluorescent probe, ARCAM 1, to monitor the aggregation of the Alzheimer's disease-associated amyloid β-peptide (Aβ). ARCAM 1 exhibits a large increase in fluorescence emission upon binding to...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Guan, Yinghua, Cao, Kevin J., Cantlon, Adam, Elbel, Kristyna, Theodorakis, Emmanuel A., Walsh, Dominic M., Yang, Jerry, Shah, Jagesh V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814290/
https://ncbi.nlm.nih.gov/pubmed/26212450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00176
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