Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys(27)) Trimethylation in Melanoma

Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication, and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cance...

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Udgivet i:Mol Cell Proteomics
Main Authors: Sengupta, Deepanwita, Byrum, Stephanie D., Avaritt, Nathan L., Davis, Lauren, Shields, Bradley, Mahmoud, Fade, Reynolds, Matthew, Orr, Lisa M., Mackintosh, Samuel G., Shalin, Sara C., Tackett, Alan J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2016
Fag:
Special Issue: Chromatin Biology and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813699/
https://ncbi.nlm.nih.gov/pubmed/26621846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.053363
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