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A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses

Preclinical and clinical data stress the importance of pharmacologically-controlling glial cell line-derived neurotrophic factor (GDNF) intracerebral administration to treat PD. The main challenge is finding a combination of a genetic switch and a drug which, when administered at a clinically-approv...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Chtarto, Abdelwahed, Humbert-Claude, Marie, Bockstael, Olivier, Das, Atze T, Boutry, Sébastien, Breger, Ludivine S, Klaver, Bep, Melas, Catherine, Barroso-Chinea, Pedro, Gonzalez-Hernandez, Tomas, Muller, Robert N, DeWitte, Olivier, Levivier, Marc, Lundberg, Cecilia, Berkhout, Ben, Tenenbaum, Liliane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813607/
https://ncbi.nlm.nih.gov/pubmed/27069954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.27
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