A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects

Mitochondria require all translational components, including aminoacyl-tRNA synthetases (aaRSs), to complete organelle protein synthesis. Some aaRS mutations cause mitochondrial disorders, including human mitochondrial threonyl-tRNA synthetase (hmtThrRS) (encoded by TARS2), the P282L mutation of whi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Yong, Zhou, Xiao-Long, Ruan, Zhi-Rong, Liu, Ru-Juan, Eriani, Gilbert, Wang, En-Duo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813579/
https://ncbi.nlm.nih.gov/pubmed/26811336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700849
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