5-Methoxyl Aesculetin Abrogates Lipopolysaccharide-Induced Inflammation by Suppressing MAPK and AP-1 Pathways in RAW 264.7 Cells

For the first time, a pale amorphous coumarin derivative, 5-methoxyl aesculetin (MOA), was isolated from the dried bark of Fraxinus rhynchophylla Hance (Oleaceae). MOA modulates cytokine expression in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, but the precise mechanisms are still not fu...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Wu, Lei, Li, Xueqin, Wu, Haifeng, Long, Wei, Jiang, Xiaojian, Shen, Ting, Qiang, Qian, Si, Chuanling, Wang, Xinfeng, Jiang, Yunyao, Hu, Weicheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813178/
https://ncbi.nlm.nih.gov/pubmed/26938526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17030315
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