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Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences

The basal ganglia (BG) promote complex sequential movements by helping to select elementary motor gestures appropriate to a given behavioral context. Indeed, Huntington’s disease (HD), which causes striatal atrophy in the BG, is characterized by hyperkinesia and chorea. How striatal cell loss alters...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Tanaka, Masashi, Singh Alvarado, Jonnathan, Murugan, Malavika, Mooney, Richard
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812762/
https://ncbi.nlm.nih.gov/pubmed/26951661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523754113
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