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Atomic resolution probe for allostery in the regulatory thin filament
Calcium binding and dissociation within the cardiac thin filament (CTF) is a fundamental regulator of normal contraction and relaxation. Although the disruption of this complex, allosterically mediated process has long been implicated in human disease, the precise atomic-level mechanisms remain opaq...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4812746/ https://ncbi.nlm.nih.gov/pubmed/26957598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519541113 |
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