Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems cannot entirely recapitulate the arrangement of cells in the brain. Here, we developed a previously unidentified 3D migratio...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Zhen-Ning, Freitas, Beatriz C., Qian, Hao, Lux, Jacques, Acab, Allan, Trujillo, Cleber A., Herai, Roberto H., Nguyen Huu, Viet Anh, Wen, Jessica H., Joshi-Barr, Shivanjali, Karpiak, Jerome V., Engler, Adam J., Fu, Xiang-Dong, Muotri, Alysson R., Almutairi, Adah
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812712/
https://ncbi.nlm.nih.gov/pubmed/26944080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521255113
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