An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep

Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme for adenosine (Ado), exhibit enhanced expression of this home...

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Vydáno v:J Neurosci
Hlavní autoři: Bjorness, Theresa E., Dale, Nicholas, Mettlach, Gabriel, Sonneborn, Alex, Sahin, Bogachan, Fienberg, Allen A., Yanagisawa, Masashi, Bibb, James A., Greene, Robert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812131/
https://ncbi.nlm.nih.gov/pubmed/27030757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3906-15.2016
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