Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke

BACKGROUND AND PURPOSE: Pentraxin 3 (PTX3) is released upon inflammatory responses in many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked whether and how PTX3 contributes to blood-brain barrier (BBB) dysfunction during the acute phase of ischemic stroke. METHODS: In...

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Gepubliceerd in:Stroke
Hoofdauteurs: Shindo, Akihiro, Maki, Takakuni, Mandeville, Emiri T., Liang, Anna C., Egawa, Naohiro, Itoh, Kanako, Itoh, Naoki, Borlongan, Mia, Holder, Julie C., Chuang, Tsu Tshen, McNeish, John D., Tomimoto, Hidekazu, Lok, Josephine, Lo, Eng H., Arai, Ken
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811738/
https://ncbi.nlm.nih.gov/pubmed/26965847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.115.012133
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