Quinidine in the Treatment of KCNT1-Positive Epilepsies

We report 2 patients with drug-resistant epilepsy caused by KCNT1 mutations who were treated with quinidine. Both mutations manifested gain of function in vitro, showing increased current that was reduced by quinidine. One, who had epilepsy of infancy with migrating focal seizures, had 80% reduction...

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Détails bibliographiques
Publié dans:Ann Neurol
Auteurs principaux: Mikati, Mohamad A, Jiang, Yong-hui, Carboni, Michael, Shashi, Vandana, Petrovski, Slave, Spillmann, Rebecca, Milligan, Carol J., Li, Melody, Grefe, Annette, McConkie, Allyn, Berkovic, Samuel, Scheffer, Ingrid, Mullen, Saul, Bonner, Melanie, Petrou, Steven, Goldstein, David
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811613/
https://ncbi.nlm.nih.gov/pubmed/26369628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24520
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