Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs and sirtuins. As cancer cells have increased NAD requirements, the main NAD salvage enzymes in humans, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosp...

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Publicat a:Oncotarget
Autors principals: Duarte-Pereira, Sara, Pereira-Castro, Isabel, Silva, Sarah S., Correia, Mariana Gonçalves, Neto, Célia, da Costa, Luís Teixeira, Amorim, António, Silva, Raquel M.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811510/
https://ncbi.nlm.nih.gov/pubmed/26675378
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