PRIMA-1(MET) induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

There is an intensive need for the development of novel drugs for the treatment of epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy due to the high recurrence rate. TP53 mutation is a common event in EOC, particularly in high-grade serous ovarian cancer, where it occurs in mor...

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Publicado no:Oncol Rep
Main Authors: YOSHIKAWA, NOBUHISA, KAJIYAMA, HIROAKI, NAKAMURA, KAE, UTSUMI, FUMI, NIIMI, KAORU, MITSUI, HIROKO, SEKIYA, RYUICHIRO, SUZUKI, SHIRO, SHIBATA, KIYOSUMI, CALLEN, DAVID, KIKKAWA, FUMITAKA
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811399/
https://ncbi.nlm.nih.gov/pubmed/26986846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2016.4653
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