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HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C dim...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Colonna, M, Borsellino, G, Falco, M, Ferrara, G B, Strominger, J L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265660/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.12000
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