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Sclerostin Immunoreactivity Increases in Cortical Bone Osteocytes and Decreases in Articular Cartilage Chondrocytes in Aging Mice

Sclerostin is a 24-kDa secreted glycoprotein that has been identified as a negative modulator of new bone formation and may play a major role in age-related decline in skeletal function. Although serum levels of sclerostin markedly increase with age, relatively little is known about whether cells in...

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Detalhes bibliográficos
Publicado no:J Histochem Cytochem
Main Authors: Thompson, Michelle L., Jimenez-Andrade, Juan Miguel, Mantyh, Patrick W.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810796/
https://ncbi.nlm.nih.gov/pubmed/26701970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155415626499
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