Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons

We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31–68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Jambunathan, Nithya, Charles, Anu-Susan, Subramanian, Ramesh, Saied, Ahmad A., Naderi, Misagh, Rider, Paul, Brylinski, Michal, Chouljenko, Vladimir N., Kousoulas, Konstantin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810717/
https://ncbi.nlm.nih.gov/pubmed/26656706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02468-15
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