Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

The transcription factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of the pancreas and the regulation of insulin gene expression in the mature pancreatic β cell. A dominant-negative frameshift mutation in the IPF-l gene was identified in a single family and shown...

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Main Authors: Macfarlane, Wendy M., Frayling, Timothy M., Ellard, Sian, Evans, Julie C., Allen, Lisa I.S., Bulman, Michael P., Ayres, Susan, Shepherd, Maggie, Clark, Penny, Millward, Ann, Demaine, Andrew, Wilkin, Terence, Docherty, Kevin, Hattersley, Andrew T.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 1999
主題:
Rapid Publication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC481047/
https://ncbi.nlm.nih.gov/pubmed/10545530
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