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Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages
The human asparaginase-like protein 1 (hASRGL1) is a member of the N-terminal nucleophile (Ntn) family that hydrolyzes L-asparagine and isoaspartyl-dipeptides. The nascent protein folds into an αβ–βα sandwich fold homodimer that cleaves its own peptide backbone at the G167–T168 bond, resulting in th...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4809669/ https://ncbi.nlm.nih.gov/pubmed/26780688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01157 |
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