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2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells

Our recent study demonstrated that sodium arsenite at a clinically relevant dose induced nephrotoxicity in human renal proximal tubular epithelial cell line HK-2, which could be inhibited by natural product 2,3,5,6-Tetramethylpyrazine (TMP) with antioxidant activity. The present study demonstrated t...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Gong, Xuezhong, Ivanov, Vladimir N., Hei, Tom K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808507/
https://ncbi.nlm.nih.gov/pubmed/26404762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1600-z
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