Aminoacyl tRNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway

OBJECTIVE: Understanding the mechanisms regulating normal and pathologic angiogenesis is of great scientific and clinical interest. In this report, we show that mutations in two different aminoacyl tRNA synthetases, threonyl tRNA synthetase (tars(y58)) or isoleucyl tRNA synthetase (iars(y68)), lead...

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Castranova, Daniel, Davis, Andrew E., Lo, Brigid D., Miller, Mayumi F., Paukstelis, Paul J., Swift, Matthew R., Pham, Van N., Torres-Vázquez, Jesús, Bell, Kameha, Shaw, Kenna M., Kamei, Makoto, Weinstein, Brant M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808418/
https://ncbi.nlm.nih.gov/pubmed/26821951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.307087
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