Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo

Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin D in this disease is lacking. To fill this knowledge gap, we determined vitamin D receptor (VDR) expression in human...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Verone-Boyle, Alissa R., Shoemaker, Suzanne, Attwood, Kristopher, Morrison, Carl D., Makowski, Andrew J., Battaglia, Sebastiano, Hershberger, Pamela A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808047/
https://ncbi.nlm.nih.gov/pubmed/26654942
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