Intra-tumor AvidinOX allows efficacy of low dose systemic biotinylated Cetuximab in a model of head and neck cancer

For locally advanced and metastatic head and neck squamous cell carcinoma (HNSCC), the current clinical use of Cetuximab in chemo/radiotherapy protocols is often associated to severe systemic toxicity. Here we report in vitro data in human FaDu pharynx SCC cells, showing that inactive concentrations...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Vesci, Loredana, Milazzo, Ferdinando Maria, Anastasi, Anna Maria, Petronzelli, Fiorella, Chiapparino, Caterina, Carollo, Valeria, Roscilli, Giuseppe, Marra, Emanuele, Luberto, Laura, Aurisicchio, Luigi, Pacello, Maria Lucrezia, Spagnoli, Luigi Giusto, De Santis, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808042/
https://ncbi.nlm.nih.gov/pubmed/26575422
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