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Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods

As cardiac cell models become increasingly complex, a correspondingly complex ‘genealogy’ of inherited parameter values has also emerged. The result has been the loss of a direct link between model parameters and experimental data, limiting both reproducibility and the ability to re-fit to new data....

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Bibliografiske detaljer
Udgivet i:R Soc Open Sci
Main Authors: Daly, Aidan C., Gavaghan, David J., Holmes, Chris, Cooper, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society Publishing 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807457/
https://ncbi.nlm.nih.gov/pubmed/27019736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.150499
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