Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the G*GC and T*AT Triplets

Implications of DNA, RNA and RNA.DNA hybrid triplexes in diverse biological functions, diseases and therapeutic applications call for a thorough understanding of their structure-function relationships. Despite exhaustive studies mechanistic rationale for the discriminatory preference of parallel DNA...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Goldsmith, Gunaseelan, Rathinavelan, Thenmalarchelvi, Yathindra, Narayanarao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807104/
https://ncbi.nlm.nih.gov/pubmed/27010368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152102
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