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Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from Escherichia coli: Simulation, Kinetics and Evolutionary Studies

Glucose 6-Phosphate Dehydrogenases (G6PDHs) from different sources show varying specificities towards NAD(+) and NADP(+) as cofactors. However, it is not known to what extent structural determinants of cofactor preference are conserved in the G6PDH family. In this work, molecular simulations, kineti...

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מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Fuentealba, Matias, Muñoz, Rodrigo, Maturana, Pablo, Krapp, Adriana, Cabrera, Ricardo
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807051/
https://ncbi.nlm.nih.gov/pubmed/27010804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152403
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