Reconciling Longitudinal Naive T-Cell and TREC Dynamics during HIV-1 Infection

Naive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have suggested that this is due to increased naive T-cell division. It remains unclear, however, how reduced naive TREC contents can be reconciled with a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Drylewicz, Julia, Vrisekoop, Nienke, Mugwagwa, Tendai, de Boer, Anne Bregje, Otto, Sigrid A., Hazenberg, Mette D., Tesselaar, Kiki, de Boer, Rob J., Borghans, José A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806918/
https://ncbi.nlm.nih.gov/pubmed/27010200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152513
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