B-cell depletion attenuates serological biomarkers of fibrosis and myofibroblast activation in IgG4-related disease

OBJECTIVES: Fibrosis is a predominant feature of IgG4-related disease (IgG4-RD). B-cell depletion induces a prompt clinical and immunological response in patients with IgG4-RD, but the effects of this intervention on fibrosis in IgG4-RD are unknown. We used the enhanced liver fibrosis (ELF) score to...

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Veröffentlicht in:Ann Rheum Dis
Hauptverfasser: Della-Torre, Emanuel, Feeney, Eoin, Deshpande, Vikram, Mattoo, Hamid, Mahajan, Vinay, Kulikova, Maria, Wallace, Zachary S, Carruthers, Mollie, Chung, Raymond T, Pillai, Shiv, Stone, John H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806785/
https://ncbi.nlm.nih.gov/pubmed/25143523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205799
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