Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

Amyloid-β, a hallmark of Alzheimer’s disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying amyloid-β positron emission tomography tracers such as carbon-11-labelled Pittsburgh compound-B. A variety of thresholds have been applied in the lit...

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Pubblicato in:Brain
Autori principali: Villeneuve, Sylvia, Rabinovici, Gil D., Cohn-Sheehy, Brendan I., Madison, Cindee, Ayakta, Nagehan, Ghosh, Pia M., La Joie, Renaud, Arthur-Bentil, Samia Kate, Vogel, Jacob W., Marks, Shawn M., Lehmann, Manja, Rosen, Howard J., Reed, Bruce, Olichney, John, Boxer, Adam L., Miller, Bruce L., Borys, Ewa, Jin, Lee-Way, Huang, Eric J., Grinberg, Lea T., DeCarli, Charles, Seeley, William W., Jagust, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806716/
https://ncbi.nlm.nih.gov/pubmed/25953778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv112
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