Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states

The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kang, Hye Suk, Cho, Ho-Chan, Lee, Jae-Ho, Oh, Goo Taeg, Koo, Seung-Hoi, Park, Byung-Hyun, Lee, In-Kyu, Choi, Hueng-Sik, Song, Dae-Kyu, Im, Seung-Soon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806307/
https://ncbi.nlm.nih.gov/pubmed/27009398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23665
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