The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (PHDs), and silencing of Phd2 induce immature...

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Pubblicato in:Cell Rep
Autori principali: Segura, Inmaculada, Lange, Christian, Knevels, Ellen, Moskalyuk, Anastasiya, Pulizzi, Rocco, Eelen, Guy, Chaze, Thibault, Tudor, Cicerone, Boulegue, Cyril, Holt, Matthew, Daelemans, Dirk, Matondo, Mariette, Ghesquière, Bart, Giugliano, Michele, Ruiz de Almodovar, Carmen, Dewerchin, Mieke, Carmeliet, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805856/
https://ncbi.nlm.nih.gov/pubmed/26972007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.047
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