Aspartate β-hydroxylase modulates cellular senescence via glycogen synthase kinase 3β in hepatocellular carcinoma

BACKGROUND & AIMS: Aspartate β-hydroxylase (ASPH) is an enzyme overexpressed in human hepatocellular carcinoma (HCC) tumors and participates in the malignant transformation process. We determined if ASPH was a therapeutic target by exerting effects on cellular senescence to retard HCC progressio...

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Pubblicato in:Hepatology
Autori principali: Iwagami, Yoshifumi, Huang, Chiung-Kuei, Olsen, Mark J., Thomas, John-Michael, Jang, Grace, Kim, Miran, Lin, Qiushi, Carlson, Rolf I., Wagner, Carl E., Dong, Xiaoqun, Wands, Jack R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805474/
https://ncbi.nlm.nih.gov/pubmed/26683595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28411
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