Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine

Cyclolipopeptides derived from the antimicrobial peptide c(Lys-Lys-Leu-Lys-Lys-Phe-Lys-Lys-Leu-Gln) (BPC194) were prepared on solid-phase and screened against four plant pathogens. The incorporation at Lys(5) of fatty acids of 4 to 9 carbon atoms led to active cyclolipopeptides. The influence on the...

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Bibliographic Details
Published in:PLoS One
Main Authors: Vilà, Sílvia, Badosa, Esther, Montesinos, Emilio, Planas, Marta, Feliu, Lidia
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805166/
https://ncbi.nlm.nih.gov/pubmed/27008420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151639
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