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Characterization of a Polyethylene Glycol-Amphotericin B Conjugate Loaded with Free AMB for Improved Antifungal Efficacy

Amphotericin B (AMB) is a highly hydrophobic antifungal, whose use is limited by its toxicity and poor solubility. To improve its solubility, AMB was reacted with a functionalized polyethylene glycol (PEG), yielding soluble complex AmB-PEG formulations that theoretically comprise of chemically conju...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Tan, Tessa Rui Min, Hoi, Kong Meng, Zhang, Peiqing, Ng, Say Kong
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805162/
https://ncbi.nlm.nih.gov/pubmed/27008086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152112
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