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NEDD8 inhibition overcomes CKS1B-induced drug resistance by upregulation of p21 in multiple myeloma
PURPOSE: CKS1B is significantly upregulated in multiple myeloma (MM) and associated with poor prognosis. The identification of novel therapies is essential for effective treatment of patients resistant to chemotherapy. The NEDD8 inhibitor MLN4924 selectively targets SCF(Skp2) activation and offers a...
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| Publicat a: | Clin Cancer Res |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4804624/ https://ncbi.nlm.nih.gov/pubmed/26156395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0254 |
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