The impact of genome-wide autozygosity on general cognitive ability

Inbreeding depression refers to lower fitness among offspring of genetic relatives (1). This reduced fitness is caused by the inheritance of two identical chromosomal segments (autozygosity) across the genome, which may expose the effects of (partially) recessive deleterious mutations. Even among ou...

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Publicado no:Mol Psychiatry
Main Authors: Howrigan, Daniel P., Simonson, Matthew A., Davies, Gail, Harris, Sarah E., Tenesa, Albert, Starr, John M., Liewald, David C, Deary, Ian J., McRae, Allan, Wright, Margaret J., Montgomery, Grant W., Hansell, Narelle, Martin, Nicholas G., Payton, Antony, Horan, Michael, Ollier, William E., Abdellaoui, Abdel, Boomsma, Dorret I., DeRosse, Pamela, Knowles, Emma E. M., Glahn, David C., Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A., Christoforou, Andrea, Steen, Vidar M., Hellard, Stephanie Le, Sundet, Kjetil, Reinvang, Ivar, Espeseth, Thomas, Lundervold, Astri J., Giegling, Ina, Konte, Bettina, Hartmann, Annette M., Rujescu, Dan, Roussos, Panos, Giakoumaki, Stella, Burdick, Katherine E., Bitsios, Panos, Donohoe, Gary, Corley, Robin, Visscher, Peter M., Pendleton, Neil, Malhotra, Anil K., Neale, Benjamin M., Lencz, Todd, Keller, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803638/
https://ncbi.nlm.nih.gov/pubmed/26390830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.120
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