The mdm-2 gene is induced in response to UV light in a p53-dependent manner.
Irradiation of mammalian cells with UV light results in a dose-dependent accumulation of the p53 tumor-suppressor gene product that is evident within 2 hr. UV treatment causes a dramatic increase in p53-specific transcriptional transactivation activity and an increase in expression of the p53-respon...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11623 |
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