Incorporating a Genetic Risk Score into Coronary Heart Disease Risk Estimates: Effect on LDL Cholesterol Levels (the MIGENES Clinical Trial)

BACKGROUND: Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS: Participan...

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Bibliographic Details
Published in:Circulation
Main Authors: Kullo, Iftikhar J., Jouni, Hayan, Austin, Erin E., Brown, Sherry-Ann, Kruisselbrink, Teresa M., Isseh, Iyad N., Haddad, Raad A., Marroush, Tariq S., Shameer, Khader, Olson, Janet E., Broeckel, Ulrich, Green, Robert C., Schaid, Daniel J., Montori, Victor M., Bailey, Kent R.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803581/
https://ncbi.nlm.nih.gov/pubmed/26915630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.115.020109
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