The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.

Using site-directed mutagenesis in conjunction with NMR structural data on the adhesion domain of human CD2, we have defined the binding region for CD58. Previous structural studies of rat and human CD2 indicate that this adhesion domain is immunoglobulin-like. Here we report that the CD58 binding s...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Arulanandam, A R, Withka, J M, Wyss, D F, Wagner, G, Kister, A, Pallai, P, Recny, M A, Reinherz, E L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7505442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11613
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